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Asparagine of z8 Insert Is Critical for the Affinity, Conformation, and Acetylcholine Receptor-clustering Activity of Neural Agrin
Agrin isoforms with different bioactivities are synthesized by the nerve and the muscle. Neural agrin containing an 8-amino acid insert (z8) introduced by alternative splicing is the active form that induces synaptic differentiation at the neuromuscular junction. In addition to alternative splicing,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934632/ https://ncbi.nlm.nih.gov/pubmed/20566625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130625 |
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