Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase–cGMP-dependent protein kinase pathway

Despite considerable concerns with pharmacological stimulation of fetal hemoglobin (Hb F) as a therapeutic option for the β-globin disorders, the molecular basis of action of Hb F-inducing agents remains unclear. Here we show that an intracellular pathway including soluble guanylate cyclase (sGC) an...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ikuta, Tohru, Ausenda, Sabrina, Cappellini, Maria D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29345/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172039/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041599798
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