Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR) diet or some small molecules. These life-extending interventions target the adaptable target of rapamycin (TOR) and cAMP/protein kinase A (cAMP/PKA) signaling pathways that are under the stringent c...

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Detalhes bibliográficos
Main Authors: Goldberg, Alexander A., Richard, Vincent R., Kyryakov, Pavlo, Bourque, Simon D., Beach, Adam, Burstein, Michelle T., Glebov, Anastasia, Koupaki, Olivia, Boukh-Viner, Tatiana, Gregg, Christopher, Juneau, Mylène, English, Ann M., Thomas, David Y., Titorenko, Vladimir I.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933888/
https://ncbi.nlm.nih.gov/pubmed/20622262
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