Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions

In eukaryotes, only a fraction of replication origins fire at each S phase. Local histone acetylation was proposed to control firing efficiency of origins, but conflicting results were obtained. We report that local histone acetylation does not reflect origin efficiencies along the adenosine monopho...

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Bibliografiske detaljer
Main Authors: Gay, Sophie, Lachages, Anne-Marie, Millot, Gael A, Courbet, Sylvain, Letessier, Anne, Debatisse, Michelle, Brison, Olivier
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933864/
https://ncbi.nlm.nih.gov/pubmed/20671737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.112
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