Tryptophan Hydroxylase 2 Genotype Determines Brain Serotonin Synthesis but Not Tissue Content in C57Bl/6 and BALB/c Congenic Mice

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis...

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Main Authors: Siesser, William B., Zhang, Xiaodong, Jacobsen, Jacob P.R., Sotnikova, Tatyana D., Gainetdinov, Raul R., Caron, Marc G.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933733/
https://ncbi.nlm.nih.gov/pubmed/20600620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.06.035
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