Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

Glioblastoma (GBM) is the most frequent malignant glioma. Treatment of GBM patients is multimodal with maximum surgical resection, followed by concurrent radiation and chemotherapy with the alkylating drug temozolomide (TMZ). The present study aims to identify genes implicated in the acquired resist...

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Detalhes bibliográficos
Main Authors: Le Calvé, Benjamin, Rynkowski, Michal, Le Mercier, Marie, Bruyère, Céline, Lonez, Caroline, Gras, Thierry, Haibe-Kains, Benjamin, Bontempi, Gianluca, Decaestecker, Christine, Ruysschaert, Jean-Marie, Kiss, Robert, Lefranc, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933693/
https://ncbi.nlm.nih.gov/pubmed/20824049
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