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BACE1(-/- )mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

BACKGROUND: BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. Examination of BACE1(-/- )mice can provide insi...

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Detalhes bibliográficos
Main Authors: Hitt, Brian D, Jaramillo, Thomas C, Chetkovich, Dane M, Vassar, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933677/
https://ncbi.nlm.nih.gov/pubmed/20731874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-31
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