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Synthesis and evaluation of new spacers for use as dsDNA endcaps

A series of aliphatic and aromatic spacer molecules designed to cap the ends of DNA duplexes have been synthesized. The spacers were converted into dimethoxytrityl protected phosphoramidites as synthons for oligonucleotides synthesis. The effect of the spacers on the stability of short DNA duplexes...

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Detalhes bibliográficos
Main Authors: Ng, Pei-Sze, Laing, Brian M., Balasundarum, Ganesan, Pingle, Maneesh, Friedman, Alan, Bergstrom, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933660/
https://ncbi.nlm.nih.gov/pubmed/20715857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100202y
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