The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells

To develop a tumor vaccine directly targeting tumor antigen to dendritic cells in situ, we engineered human mesothelin (MSLN) into an antibody specific for mouse DEC-205, a receptor for antigen presentation. We then characterized both T cell and humoral responses to human MSLN and compared immunizin...

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Hlavní autoři: Wang, Bei, Kuroiwa, Janelle M.Y., He, Li-Zhen, Charalambous, Anna, Keler, Tibor, Steinman, Ralph M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933265/
https://ncbi.nlm.nih.gov/pubmed/19769731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2009.04933.x
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