Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

The Jun N-terminal kinases (JNKs) recently have been shown to be required for thymocyte apoptosis and T cell differentiation and/or proliferation. To investigate the molecular targets of JNK signaling in lymphoid cells, we used mice in which the serines phosphorylated by JNK in c-Jun were replaced b...

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Bibliographic Details
Main Authors: Behrens, Axel, Sabapathy, Kanaga, Graef, Isabella, Cleary, Mike, Crabtree, Gerald R., Wagner, Erwin F.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC29332/
https://ncbi.nlm.nih.gov/pubmed/11172026
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