Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†

[Image: see text] We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the neuraminidase (NA), which confers cross-resistance to all NA inhibitors. We analyzed enzyme properties of the D197 and E197 NAs and compared these to a D197N NA, known to arise after oseltamivir...

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Autores principales: Oakley, Aaron J., Barrett, Susan, Peat, Thomas S., Newman, Janet, Streltsov, Victor A., Waddington, Lynne, Saito, Takehiko, Tashiro, Masato, McKimm-Breschkin, Jennifer L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2010
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932999/
https://ncbi.nlm.nih.gov/pubmed/20695427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100621s
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