Crucial role of the central leptin receptor in murine Trypanosoma cruzi infection

Mice carrying a defective leptin receptor gene (db/db) are metabolically challenged and upon infection with Trypanosoma cruzi (Brazil strain) suffer high mortality. In a genetically modified db/db mouse, the NSE-Rb db/db, central leptin signaling is reconstituted only in the brain which is sufficien...

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Bibliografiske detaljer
Main Authors: Nagajyothi, Fnu, Zhao, Dazhi, Machado, Fabiana S., Weiss, Louis M., Schwartz, Gary J., Desruisseaux, Mahalia S., Zhao, Yang, Factor, Stephen M., Huang, Huan, Albanese, Chris, Teixeira, Mauro M., Scherer, Philipp E., Chua, Streamson C., Tanowitz, Herbert B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932826/
https://ncbi.nlm.nih.gov/pubmed/20726767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/656189
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