Crucial role of the central leptin receptor in murine Trypanosoma cruzi infection

Mice carrying a defective leptin receptor gene (db/db) are metabolically challenged and upon infection with Trypanosoma cruzi (Brazil strain) suffer high mortality. In a genetically modified db/db mouse, the NSE-Rb db/db, central leptin signaling is reconstituted only in the brain which is sufficien...

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Hauptverfasser: Nagajyothi, Fnu, Zhao, Dazhi, Machado, Fabiana S., Weiss, Louis M., Schwartz, Gary J., Desruisseaux, Mahalia S., Zhao, Yang, Factor, Stephen M., Huang, Huan, Albanese, Chris, Teixeira, Mauro M., Scherer, Philipp E., Chua, Streamson C., Tanowitz, Herbert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932826/
https://ncbi.nlm.nih.gov/pubmed/20726767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/656189
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