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Selective Kinase Inhibition by Exploiting Differential Pathway Sensitivity
Protein kinase inhibitors are optimized to have high affinity for their intended target(s) to elicit the desired cellular effects. Here, we asked whether differences in inhibitory sensitivity between two kinase signaling pathways, controlled by the cyclin-dependent kinases Cdk1 and Pho85, can be suf...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932700/ https://ncbi.nlm.nih.gov/pubmed/16632252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.02.004 |
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