Humanized nonobese diabetic-scid IL2rγ(null) mice are susceptible to lethal Salmonella Typhi infection

Salmonella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to cause disease in mice. Here, we show that S. Typhi can replicate in vivo in nonobese diabetic (NOD)-scid IL2rγ(null) mice engrafted with human hematopoietic stem cells (hu-SRC-SCID mice) to cause a...

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Detalhes bibliográficos
Main Authors: Libby, Stephen J., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., McClelland, Michael, Smith, Kelly D., Cookson, Brad T., Karlinsey, Joyce E., Kinkel, Traci L., Porwollik, Steffen, Canals, Rocio, Cummings, Lisa A., Fang, Ferric C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932584/
https://ncbi.nlm.nih.gov/pubmed/20713716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005566107
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