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CpG island clusters and pro-epigenetic selection for CpGs in protein-coding exons of HOX and other transcription factors
CpG dinucleotides contribute to epigenetic mechanisms by being the only site for DNA methylation in mammalian somatic cells. They are also mutation hotspots and ∼5-fold depleted genome-wide. We report here a study focused on CpG sites in the coding regions of Hox and other transcription factor genes...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932574/ https://ncbi.nlm.nih.gov/pubmed/20716685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010506107 |
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