Modulation of the Inhibitor Properties of Dipeptidyl (Acyloxy)methyl Ketones Toward the CaaX Proteases

Dipeptidyl (acyloxy)methyl ketones (AOMKs) have been identified as mechanism-based inhibitors of certain cysteine proteases. These compounds are also inhibitors of the integral membrane proteins Rce1p and Ste24p, which are proteases that independently mediate a cleavage step associated with the matu...

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Main Authors: Dechert, Anne-Marie R., MacNamara, James P., Breevoort, Sarah R., Hildebrandt, Emily R., Hembree, Ned W., Rea, Adam C., McLain, Duncan E., Porter, Stephen B., Schmidt, Walter K., Dore, Timothy M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932464/
https://ncbi.nlm.nih.gov/pubmed/20696584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.07.041
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