Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(−) T cells that express the same antigen-specific receptor

CD8(+) and CD8(−) T cell lines expressing the same antigen-specific receptor [the 2C T cell receptor (TCR)] were compared for ability to bind soluble peptide-MHC and to lyse target cells. The 2C TCR on CD8(−) cells bound a syngeneic MHC (K(b+))-peptide complex 10–100 times less well than the same TC...

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Détails bibliographiques
Auteurs principaux: Cho, Bryan K., Lian, Kuo-Chiang, Lee, Peter, Brunmark, Anders, McKinley, Carol, Chen, Jianzhu, Kranz, David M., Eisen, Herman N.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2001
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC29324/
https://ncbi.nlm.nih.gov/pubmed/11172018
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