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Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

The activity of transcription factor FoxO1 is regulated by phosphorylation-dependent nuclear exclusion and deacetylation-dependent nuclear retention. It is unclear whether and how these two post-translational modifications affect each other. To answer this question, we expressed FoxO1 cDNAs with com...

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Detalhes bibliográficos
Main Authors: Qiang, Li, Banks, Alexander S., Accili, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930737/
https://ncbi.nlm.nih.gov/pubmed/20519497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.140228
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