Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

Patients carrying mutations within the amyloid-β (Aβ) sequence develop severe early-onset cerebral amyloid angiopathy with some of the related variants manifesting primarily with hemorrhagic phenotypes. Matrix metalloproteases (MMPs) are typically associated with blood brain barrier disruption and h...

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Autori principali: Hernandez-Guillamon, Mar, Mawhirt, Stephanie, Fossati, Silvia, Blais, Steven, Pares, Mireia, Penalba, Anna, Boada, Merce, Couraud, Pierre-Olivier, Neubert, Thomas A., Montaner, Joan, Ghiso, Jorge, Rostagno, Agueda
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930713/
https://ncbi.nlm.nih.gov/pubmed/20576603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135228
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