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c-Cbl Facilitates Endocytosis and Lysosomal Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway Epithelial Cells

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(−) channel expressed in the apical membrane of fluid-transporting epithelia. The apical membrane density of CFTR channels is determined, in part, by endocytosis and the postendocytic sorting of CFTR for lysosomal degra...

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Bibliografiske detaljer
Main Authors: Ye, Siying, Cihil, Kristine, Stolz, Donna Beer, Pilewski, Joseph M., Stanton, Bruce A., Swiatecka-Urban, Agnieszka
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930700/
https://ncbi.nlm.nih.gov/pubmed/20525683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139881
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