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A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway

Mutant larvae for the Drosophila gene lethal giant larva (lgl) develop neoplastic tumors in imaginal discs. However, lgl mutant clones do not form tumors when surrounded by wild-type tissue, suggesting the existence of a tumor-suppressing mechanism. We have investigated the tumorigenic potential of...

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Autori principali: Menéndez, Javier, Pérez-Garijo, Ainhoa, Calleja, Manuel, Morata, Ginés
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930466/
https://ncbi.nlm.nih.gov/pubmed/20679206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009376107
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