Stabilization of Anionic and Neutral Forms of a Fluorophoric Ligand at the Active Site of Human Carbonic Anhydrase I

We synthesized a fluorogenic dansylamide derivative (JB2-48), which fills the entire (15 Å deep) active site pocket of human carbonic anhydrase I, and investigated the contributions of sulfonamide and hydrophobic regions of the ligand structure on the spectral, kinetic, and thermodynamic properties...

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Hlavní autoři: Manokaran, Sumathra, Banerjee, Jayati, Mallik, Sanku, Srivastava, D. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930141/
https://ncbi.nlm.nih.gov/pubmed/20620244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.06.024
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