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Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II

Despite the similarity in the active site pockets of carbonic anhydrase (CA) isozymes I and II, the binding affinities of benzenesulfonamide inhibitors are invariably higher with CA II as compared to CA I. To explore the structural basis of this molecular recognition phenomenon, we have designed and...

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Detalhes bibliográficos
Main Authors: Srivastava, D. K., Jude, Kevin M., Banerjee, Abir L., Haldar, Manas, Manokaran, Sumathra, Kooren, Joel, Mallik, Sanku, Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532950/
https://ncbi.nlm.nih.gov/pubmed/17407288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja068359w
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