Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule–encoding genes, including 2 that encode autoantigens: proteinase 3 (PR3) and myeloperoxidase (MPO). To uncover a potential transcripti...

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Detalhes bibliográficos
Main Authors: Ciavatta, Dominic J., Yang, JiaJin, Preston, Gloria A., Badhwar, Anshul K., Xiao, Hong, Hewins, Peter, Nester, Carla M., Pendergraft, William F., Magnuson, Terry R., Jennette, J. Charles, Falk, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929711/
https://ncbi.nlm.nih.gov/pubmed/20714105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40034
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