Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose Binding Lectin

SUMMARY: An intact complement system is crucial for limiting West Nile virus (WNV) dissemination. Herein, we define how complement directly restricts flavivirus infection in an antibody-independent fashion. Mannose binding lectin (MBL) recognized N-linked glycans on the structural proteins of WNV an...

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Main Authors: Fuchs, Anja, Lin, Tsai-Yu, Beasley, David W., Stover, Cordula M., Schwaeble, Wilhelm J., Pierson, Theodore C., Diamond, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929649/
https://ncbi.nlm.nih.gov/pubmed/20709295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.07.007
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