Pathogenesis of Hemolytic Anemia in Homozygous Hemoglobin C Disease

Hemoglobin C is less soluble than hemoglobin A in red cells, in hemolysates, and in dilute phosphate buffer. Its relative insolubility may be explained by electrostatic interactions between positively charged β6-lysyl groups and negatively charged groups on adjacent molecules. Red cells from patient...

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Bibliographic Details
Main Authors: Charache, Samuel, Conley, C. Lockard, Waugh, David F., Ugoretz, Richard J., Spurrell, J. Richard
Format: Artigo
Language:Inglês
Published: 1967
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC292930/
https://ncbi.nlm.nih.gov/pubmed/6061750
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