Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome

The abnormal spine morphology found in fragile X syndrome (FXS) is suggestive of an error in the signaling cascades that organize the actin cytoskeleton. We report here that physiological activation of the small GTPase Rac1 and its effector p-21 activated kinase (PAK), two enzymes critically involve...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Lulu Y., Rex, Christopher S., Babayan, Alex H., Kramár, Eniko A., Lynch, Gary, Gall, Christine M., Lauterborn, Julie C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929244/
https://ncbi.nlm.nih.gov/pubmed/20720104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1077-10.2010
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