Epigenetic Down-Regulation of the Tumor Suppressor Gene PRDM1/Blimp-1 in Diffuse Large B Cell Lymphomas : A Potential Role of the MicroRNA Let-7

PRDM1/Blimp-1, a master regulator for B cell terminal differentiation, is a putative tumor suppressor in diffuse large B cell lymphomas (DLBCL). Inactivating mutations of PRDM1 have been previously identified in a subset of nongerminal center B cell–like (GCB) DLBCL. We investigated the presence of...

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Detalhes bibliográficos
Main Authors: Nie, Kui, Zhang, Taotao, Allawi, Hatim, Gomez, Mario, Liu, Yifang, Chadburn, Amy, Wang, Y. Lynn, Knowles, Daniel M., Tam, Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928978/
https://ncbi.nlm.nih.gov/pubmed/20651244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091291
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