Cigarette Smoke-Related Hydroquinone Induces Filamentous Actin Reorganization and Heat Shock Protein 27 Phosphorylation through p38 and Extracellular Signal-Regulated Kinase 1/2 in Retinal Pigment Epithelium : Implications for Age-Related Macular Degeneration

Retinal pigment epithelium (RPE)-derived membranous debris named blebs, may accumulate and contribute to sub-RPE deposit formation, which is the earliest sign of age-related macular degeneration (AMD). Oxidative injury to the RPE might play a significant role in AMD. However, the underlying mechanis...

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Detalhes bibliográficos
Main Authors: Pons, Marianne, Cousins, Scott W., Csaky, Karl G., Striker, Gary, Marin-Castaño, Maria E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928954/
https://ncbi.nlm.nih.gov/pubmed/20651235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091108
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