A Combination of Hypoxia and Lipopolysaccharide Activates Tristetraprolin to Destabilize Proinflammatory mRNAs such as Tumor Necrosis Factor-α

Inflammation is often accompanied by hypoxia because of the high oxygen consumption of invading bacteria and immune cells. During resolution of inflammation, the formation of inflammatory mediators such as tumor necrosis factor-α (TNF-α), which is produced by macrophages, needs to be terminated. We...

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Bibliografski detalji
Glavni autori: Werno, Christian, Schmid, Tobias, Schnitzer, Steffen E., Peters, Kathrin, Milke, Larissa, Brüne, Bernhard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2010
Teme:
Regular Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928945/
https://ncbi.nlm.nih.gov/pubmed/20639458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091212
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