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GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through its cognate receptors death receptor 4 (DR4) and death receptor 5 (DR5), preferentially in malignant cells. However, many malignant cells remain resistant to TRAIL cytotoxicity by poorly characterized mechanism...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928864/ https://ncbi.nlm.nih.gov/pubmed/20562908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.235 |
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