A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expres...

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Main Authors: Riddick, Nadeene E., Hermann, Emilia A., Loftin, Lamorris M., Elliott, Sarah T., Wey, Winston C., Cervasi, Barbara, Taaffe, Jessica, Engram, Jessica C., Li, Bing, Else, James G., Li, Yingying, Hahn, Beatrice H., Derdeyn, Cynthia A., Sodora, Donald L., Apetrei, Cristian, Paiardini, Mirko, Silvestri, Guido, Collman, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928783/
https://ncbi.nlm.nih.gov/pubmed/20865163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001064
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