Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity

CCR4, an evolutionarily conserved member of the CCR4–NOT complex, is the main cytoplasmic deadenylase. It contains a C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of enzymes. We have determined the high-resolution three-dimensional structure of the...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Wang, Hui, Morita, Masahiro, Yang, Xiuna, Suzuki, Toru, Yang, Wen, Wang, Jiao, Ito, Kentaro, Wang, Quan, Zhao, Cong, Bartlam, Mark, Yamamoto, Tadashi, Rao, Zihe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928688/
https://ncbi.nlm.nih.gov/pubmed/20628353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.152
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker