Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is the mono-ubiquitination of histone H2A by the combined action of the Posterior sex combs (Psc) and Sex combs extra (Sce) proteins. Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-pur...

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Détails bibliographiques
Auteurs principaux: Maertens, Goedele N, El Messaoudi-Aubert, Selma, Elderkin, Sarah, Hiom, Kevin, Peters, Gordon
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928679/
https://ncbi.nlm.nih.gov/pubmed/20601937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.129
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