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Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 ω-hydroxylase activity
With the onset of ventilation at birth, cerebral blood flow decreases as oxygenation increases, but the mechanism of cerebral vasoconstriction is unknown. Cytochrome P-450 ω-hydroxylase activity metabolizes arachidonic acid to 20-HETE, a potent vasoconstrictor, in a physiologically relevant O(2)-dep...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928585/ https://ncbi.nlm.nih.gov/pubmed/20489034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01090.2009 |
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