Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity

Diabetes mellitus (DM) is closely related to cardiovascular morbidity and mortality, but the specific molecular basis linking DM with increased vulnerability to cardiovascular injury remains incompletely understood. Methylglyoxal (MG), a precursor to advanced glycation end products (AGEs), is increa...

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Main Authors: Wang, Xiao-Liang, Lau, Wayne B., Yuan, Yue-Xing, Wang, Ya-Jing, Yi, Wei, Christopher, Theodore A., Lopez, Bernard L., Liu, Hui-Rong, Ma, Xin-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928516/
https://ncbi.nlm.nih.gov/pubmed/20460580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00215.2010
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