Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic β-cells

We report localization of a cytosolic protein histidine phosphatase (PHP; ∼16 kDa) in INS 832/13 cells, normal rat islets, and human islets. siRNA-mediated knockdown of PHP markedly reduced glucose- or mitochondrial fuel-induced but not KCl-induced insulin secretion. siRNA-mediated knockdown of PHP...

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Detalhes bibliográficos
Main Authors: Kamath, Vasudeva, Kyathanahalli, Chandrashekara N., Jayaram, Bhavaani, Syed, Ismail, Olson, Lawrence Karl, Ludwig, Katrin, Klumpp, Susanne, Krieglstein, Josef, Kowluru, Anjaneyulu
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928511/
https://ncbi.nlm.nih.gov/pubmed/20501872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00091.2010
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