PIK3CA Hotspot Mutation Scanning by a Novel and Highly Sensitive High-Resolution Small Amplicon Melting Analysis Method

Somatic mutations in the PIK3CA gene have been discovered in many human cancers, and their presence correlates to therapy response. Three “hotspot” mutations within the PIK3CA gene are localized in exons 9 and 20. High-resolution melting analysis (HRMA) is a highly sensitive, robust, rapid, and cost...

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Bibliografiske detaljer
Main Authors: Vorkas, Panagiotis A., Poumpouridou, Nikoleta, Agelaki, Sophia, Kroupis, Christos, Georgoulias, Vassilis, Lianidou, Evi S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928435/
https://ncbi.nlm.nih.gov/pubmed/20616362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.100008
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