Centrally Administered Pertussis Toxin Inhibits Microglia Migration to the Spinal Cord and Prevents Dissemination of Disease in an EAE Mouse Model

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or multiple sclerosis (MS). PTx has pleotropic effects o...

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Detalhes bibliográficos
Main Authors: Yin, Jun-xiang, Tu, Jiang-long, Lin, Hao-jie, Shi, Fu-dong, Liu, Ru-lan, Zhao, Chong-bo, Coons, Stephen W., Kuniyoshi, Sandra, Shi, Jiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928301/
https://ncbi.nlm.nih.gov/pubmed/20811645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012400
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