Centrally Administered Pertussis Toxin Inhibits Microglia Migration to the Spinal Cord and Prevents Dissemination of Disease in an EAE Mouse Model

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or multiple sclerosis (MS). PTx has pleotropic effects o...

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Main Authors: Yin, Jun-xiang, Tu, Jiang-long, Lin, Hao-jie, Shi, Fu-dong, Liu, Ru-lan, Zhao, Chong-bo, Coons, Stephen W., Kuniyoshi, Sandra, Shi, Jiong
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928301/
https://ncbi.nlm.nih.gov/pubmed/20811645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012400
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