Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

BACKGROUND: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequ...

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Detalhes bibliográficos
Main Authors: Hov, Johannes R., Keitel, Verena, Laerdahl, Jon K., Spomer, Lina, Ellinghaus, Eva, ElSharawy, Abdou, Melum, Espen, Boberg, Kirsten M., Manke, Thomas, Balschun, Tobias, Schramm, Christoph, Bergquist, Annika, Weismüller, Tobias, Gotthardt, Daniel, Rust, Christian, Henckaerts, Liesbet, Onnie, Clive M., Weersma, Rinse K., Sterneck, Martina, Teufel, Andreas, Runz, Heiko, Stiehl, Adolf, Ponsioen, Cyriel Y., Wijmenga, Cisca, Vatn, Morten H., Stokkers, Pieter C. F., Vermeire, Severine, Mathew, Christopher G., Lie, Benedicte A., Beuers, Ulrich, Manns, Michael P., Schreiber, Stefan, Schrumpf, Erik, Häussinger, Dieter, Franke, Andre, Karlsen, Tom H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928275/
https://ncbi.nlm.nih.gov/pubmed/20811628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012403
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