Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

Nitric oxide (NO) produced by macrophages is toxic to host tissues and invading pathogens and its regulation is therefore essential to suppress host cytotoxicity. Macrophage arginase 1 (Arg1) inhibits the production of NO by competing with NO synthases for arginine, the common substrate of NO syntha...

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Detalhes bibliográficos
Main Authors: Qualls, Joseph E., Neale, Geoffrey, Smith, Amber M., Koo, Mi-Sun, DeFreitas, Ashley A., Zhang, Huiyuan, Kaplan, Gilla, Watowich, Stephanie S., Murray, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928148/
https://ncbi.nlm.nih.gov/pubmed/20716764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000955
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