Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma

BACKGROUND: The product of CDKN2A, p16 is an essential regulator of the cell cycle controlling the entry into the S-phase. Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiation of hepatocellular carcinoma (HCC) from other liver tumors. METHODS: Tumor and...

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Bibliografiske detaljer
Main Authors: Csepregi, Antal, Ebert, Matthias PA, Röcken, Christoph, Schneider-Stock, Regine, Hoffmann, Juliane, Schulz, Hans-Ulrich, Roessner, Albert, Malfertheiner, Peter
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927998/
https://ncbi.nlm.nih.gov/pubmed/20569442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-317
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