Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress

OBJECTIVE: Cellular stress and proinflammatory cytokines induce phosphorylation of insulin receptor substrate (IRS) proteins at Ser sites that inhibit insulin and IGF-1 signaling. Here, we examined the role of Ser phosphorylation of IRS-2 in mediating the inhibitory effects of proinflammatory cytoki...

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Bibliographic Details
Main Authors: Gurevitch, Diana, Boura-Halfon, Sigalit, Isaac, Roi, Shahaf, Galit, Alberstein, Moti, Ronen, Denise, Lewis, Eli C., Zick, Yehiel
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2010
Subjects:
Islet Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927941/
https://ncbi.nlm.nih.gov/pubmed/20547979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0890
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