Deficiency of Antigen Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

BACKGROUND: Adaptive and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen presenting cell (APC) antigen presentation and T cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist athero...

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Detalhes bibliográficos
Main Authors: Sun, Jiusong, Hartvigsen, Karsten, Chou, Meng-Yun, Zhang, Yadong, Sukhova, Galina K., Zhang, Jie, Lopez-Ilasaca, Marco, Diehl, Cody J., Yakov, Niva, Harats, Dror, George, Jacob, Witztum, Joseph L., Libby, Peter, Ploegh, Hidde, Shi, Guo-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927799/
https://ncbi.nlm.nih.gov/pubmed/20697023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.891887
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