Cystatin C Deficiency Promotes Inflammation in Angiotensin II–Induced Abdominal Aortic Aneurisms in Atherosclerotic Mice

An imbalance between cysteinyl cathepsins and their principal endogenous inhibitor cystatin C (CystC) may favor proteolysis in the pathogenesis of human abdominal aortic aneurysms (AAA), yet a direct role of CystC in AAA remains unproven. This study used CystC and apolipoprotein E (ApoE) compound mu...

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Autors principals: Schulte, Stephanie, Sun, Jiusong, Libby, Peter, MacFarlane, Lindsey, Sun, Chongxiu, Lopez-Ilasaca, Marco, Shi, Guo-Ping, Sukhova, Galina K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2010
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893687/
https://ncbi.nlm.nih.gov/pubmed/20472891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090381
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