Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2(ΔGF122)) and structural roles of F122 in target recognition

BACKGROUND: ALG-2 (a gene product of PDCD6) belongs to the penta-EF-hand (PEF) protein family and Ca(2+)-dependently interacts with various intracellular proteins including mammalian Alix, an adaptor protein in the ESCRT system. Our previous X-ray crystal structural analyses revealed that binding of...

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Huvudupphovsmän: Inuzuka, Tatsutoshi, Suzuki, Hironori, Kawasaki, Masato, Shibata, Hideki, Wakatsuki, Soichi, Maki, Masatoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927601/
https://ncbi.nlm.nih.gov/pubmed/20691033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-10-25
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