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Type I interferon reverses human Th2 commitment and stability by suppressing GATA3
Th2 cells regulate inflammatory responses to helminth infections while also mediating pathological processes of asthma and allergy. IL-4 promotes Th2 development by inducing the expression of the GATA3 transcription factor, and the Th2 phenotype is stabilized by a GATA3-dependent auto-regulatory loo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2927323/ https://ncbi.nlm.nih.gov/pubmed/20554961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000469 |
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