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An Efficient System For the Pd-Catalyzed Cross-Coupling of Amides and Aryl Chlorides

A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent....

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Detalhes bibliográficos
Main Authors: Fors, Brett P., Dooleweerdt, Karin, Zeng, Qingle, Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927134/
https://ncbi.nlm.nih.gov/pubmed/20740063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.04.096
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