Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice

Alzheimer's disease (AD) is a progressive dementing disorder characterized by age-related amyloid-beta (Aβ) deposition, neurofibrillary tangles, and synapse and neuronal loss. It is widely recognized that Aβ is a principal pathogenic mediator of AD. Our goal was to develop an immunotherapeutic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ryan, Deborah A, Mastrangelo, Michael A, Narrow, Wade C, Sullivan, Mark A, Federoff, Howard J, Bowers, William J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927061/
https://ncbi.nlm.nih.gov/pubmed/20551911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.111
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados